PLAQUE PROGRESSION MODELING BY USING HEMODYNAMIC SIMULATION AND HISTOLOGICAL DATA
Z.Milosevic, M.Radovic, J.Bird, Z.Teng, M.Obradovic, I.Saveljic, S.Savic and N.Filipovic (UDC: 532.54:612.117)
Abstract:
Atherosclerosis is a disease of large arteries that is characterized by the accumulation of lipids in the arterial wall. Mechanical forces such as low shear stress are implicated in plaque formation and development. The objective of this work is to examine influence of wall shear stress (WSS) and histological and blood analysis data on the atherosclerosis development. Histological data and blood analysis (cholesterol, HDL, LDL and triglycerides) are available for 18 rabbits fed by atherogenic diet at Cambridge University. WSS data are calculated by using Computer Fluid Dynamic (CFD). Navier-Stokes equations and Darcy`s law were main governing methods for modeling fluid dynamics in the lumen and wall. Convection diffusion equations were used for modeling LDL and oxygen transport. For coupling fluid dynamics and solute dynamics Kedem-Katchalsky equations were used. Two types of finite element model were used. Wall free models were wall is treated only as boundary condition and single layered model where intima and media of the wall is treated as one entity with homogenous transport characteristics.
