MODELING OF PLAQUE FORMATION AND DEVELOPMENT IN ARTREAT AND TAXINOMISIS PROJECTS
Nenad Filipović, Miloš Radović, Tijana Đukić, Igor Saveljić, Bogdan Milićević, Exarchos Themis, Oberdan Parodi, Dimitris Fotiadis (DOI: 10.24874/jsscm.2025.19.01.16)
Abstract
This review summarizes scientific findings from three European Commission FP7 projects. The first, ARTREAT (2008-2013), focused on a multi-level, patient-specific model of artery and atherogenesis for outcome prediction, treatment decision support, and virtual hands-on training. An original method for plaque formation and development was created and validated using pilot study patients with coronary and carotid artery disease in EU clinical centers. Additionally, results from the TAXINOMISIS project (2018-2024) are discussed. This project aimed to develop a multidisciplinary approach to stratify patients with carotid artery disease, employing continuum and Agent-Based Modeling (ABM) techniques to study plaque progression. The goal was to create an innovative, multiscale risk stratification model that integrates clinical and personalized data, plaque and brain imaging, computational modeling, and novel biomarkers to distinguish high-risk from low-risk patients. Researchers from University of Kragujevac and BioIRC participated in this project with colleagues from European Union.
